About

Pathology Core

 

 

The pathology core is now located in Colket Translational Research Building (CTRB) in the A level room A410. 

Here are directions for where to find us.  We look forward to working with you!

 

UPENN User Access:

Colket Translational Building A Level is currently accessible thru card access only.  In order for UPENN users to access the building a CHOP "Token" must be obtained with security to allow you to swipe into the elevators with your ID badge.  Instructions for obtaining a token are located here:

 

https://www.research.chop.edu/sites/default/files/web/sites/default/files/pdfs/How_to_Obtain_A_CHOP_Token.pdf

 

 Once you have obtained your token contact Dan Martinez:  martinezd@chop.edu in order to have security add you to the list for the A level elevators.  CHOP Tokens must be renewed annually.

 

Overview of Services

 

 

 

 

 

 

The Pathology Core Laboratory at the Research Institute at Children's Hospital of Philadelphia provides basic histopathology, research immunohistochemistry, tissue microarray, and digital slide scanning services to researchers at Children's Hospital of Philadelphia and within the surrounding academic community. We offer a full range of histopathology services for both paraffin-embedded and frozen tissue samples including tissue processing, embedding, and cutting. We also perform most standard stains as well as immunohistochemistry, antibody workup, fluorescence, in situ hybridization and TUNEL. Tissue microarrays can be constructed and our staining services may be used on slides acquired from the arrays. Sophisticated imaging instrumentation is available for both bright field and fluorescent microscopy including whole slide scanning. We also host specialized software to analyze, manage, and store data on stained tissues and arrays.


We are located in the A Level of Colket Tranlational Research Center (CTRB) in room A410. Daniel Martinez (267-426-5635 martinezd@email.chop.edu) is the Lab Director and can address all questions regarding basic histopathology, research immunohistochemistry, tissue microarray and imaging. Dr. Ben Wilkinsoni, M.D./PhD. is the Faculty Director.

 

If you publish research supported by the core facility please include us in your acknowledgments:

“We thank the Pathology Core Laboratory at the Children’s Hospital of Philadelphia Research Institute for providing                           services”

 

News

Hi all,

 

Please join us for the seminar to introduce new technology to use at CHOP for Spatial Proteomics.  The Microscoop Platform, is a cutting-edge, microscopy-based system that enables spatially resolved, unbiased proteomic discovery at subcellular resolution and provides a unique technological capability not available elsewhere in the region, enabling experiments that were previously not possible.  Below and attached is the flyer. 

 

Technology Summary

The Microscoop system represents a transformative advancement for spatial proteomics by enabling hypothesis-free, high-precision identification of proteins from specific cellular and subcellular structures. Unlike antibody- or aptamer-based spatial profiling, which is restricted to predefined target panels, Microscoop performs unbiased discovery using AI-driven image segmentation, two-photon patterned photolabeling, and real-time imaging. This allows investigators to isolate proteomes from organelles, cell–cell contact sites, microdomains, and disease-associated structures that are inaccessible to classical spatial techniques. 

 

This is supported by the Children's Hospital of Philadelphia-New Technology Instrumentation (NTI) Grant, the Department of Pathology and Laboratory Medicine, and the Department of Pediatrics.

 

 A virtual option is also available via Zoom: 

 

"Unbiased Spatial Proteimics at Subcellular Precision"

Wednesday March 4th 2026

1-2pm ARC Room 805

 

 

 

Leadership & Staff

Daniel Martinez | Technical Director
267-426-5635
martinezd@chop.edu


Benjamin J Wilkins, MD, PhD | Faculty Director
267-426-0174
wilkinsb@chop.edu

 

Socrates Agrio | Research Assistant
agrio@chop.edu

Tyler Skinner | Research Assistant
skinnert@chop.edu

Zoe Freeman | Research Assistant
freemanz@chop.edu 

 

 

Location and hours of operation

Hours  Location

9am-5pm

 3501 Civic Ctr Blvd
 CTRB Rm A410
 Philadelphia, PA 19104

Links and Resources

  1. Pathology Core Laboratories

Contacts

Name Role Phone Email Location
Dan Martinez
Technical Director
 
267-426-5635
 
MARTINEZD@CHOP.EDU
 
CTRB A410
 

Service list


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